Jember Medical Journal

Effectivity of Pyridoxine as Adjuvant Therapy of Phenytoin in Patients with Epilepsy at Soebandi Regional Hospital Jember

Yovita Karina Pandan Putri
Faculty of Medicine, University of Jember, Indonesia

Cholis Abrori
Departement of Pharmachology, Faculty of Medicine, University of Jember

Komang Yunita Wiryaning Putri
Department of Neurology, Soebandi Regional Hospital, Jember, Indonesia

DOI: https://doi.org/10.19184/jembermedicaljournal.v2i2.150

Abstract

PPhenytoin is an antiepileptic drug used as monotherapy for partial and generalized tonic- clonic seizures for more than 50 years. Pyridoxine is a water-soluble vitamin widely used for seizure patients unresponsive to standard treatment regimens. This study was conducted to determine the effect of pyridoxine as adjuvant therapy in epilepsy patients receiving phenytoin and to determine the relationship between age, gender, type of epilepsy, and duration of therapy on the incidence of seizures in epilepsy patients at Soebandi Regional Hospital Jember. This research is an observational analytic study with a cross sectional design. The data was taken from the patient's medical record at Soebandi Regional Hospital Jember. The number of samples in each treatment group (phenytoin with pyridoxine adjuvant and monotherapy phenytoin) was 18 samples so the total number of samples in this study was 36 samples. Samples were taken using total sampling technique. Data analysis was performed using Chi-Square test on bivariate analysis and The Logistic test on multivariate analysis. The sample in this study was dominated by male patients (52.8%), aged 19-59 years (52.8%), had epilepsy with generalized seizure type (86.1%), and received therapy for < 3 years (77.8%). The results of bivariate and multivariate analysis showed correlation between the administration of pyridoxine and the incidence of seizures, indicating that phenytoin therapy with pyridoxine adjuvants was more effective than monotherapy phenytoin. Other factors such as gender, age, type of epilepsy, and duration of therapy were not proven to have a correlation with the incidence of seizures in epilepsy patients at Soebandi Regional Hospital Jember.

Keyword: Epilepsy, pyridoxine, phenytoin

REFERENCE

Asif, M. (2013). Role of various vitamins in the patients with epilepsy. International Journal of Pharmacological Research, 3(1), 1–9. https://doi.org/10.7439/ijpr
Beghi, E. (2020). The Epidemiology of Epilepsy. Neuroepidemiology, 54(2), 185–191. https://doi.org/10.1159/000503831
Chang, H. H., Sung, P. S., Liao, W. C., Chang, A. Y. W., Hsiao, Y. H., Fu, T. F., Huang,
C. Y., & Huang, C. W. (2020). An open pilot study of the effect and tolerability of add-on multivitamin therapy in patients with intractable focal epilepsy. Nutrients, 12(8), 2359. https://doi.org/10.3390/nu12082359
Ekaputri, T. W., Verbty, N. A., & Kusdyah, E. (2020). Karakteristik pasien epilepsi di Rumah Sakit Kota Jambi periode Januari sampai Desember 2018. Jurnal Medika Malahayat, 4(2), 112–119.
Fiest, K. M., Sauro, K. M., Wiebe, S., Patten, S. B., Dykeman, J., Pringsheim, T., & Lorenzetti, D. L. (2017). Prevalence and incidence of epilepsy: A systematic review and meta-analysis of international studies. Neurology, 88(3), 296–303.
Gerlach, A. T., Thomas, S., Stawicki, S. P., Whitmill, M. L., Steinberg, S. M., & Cook,
C. H. (2011). Vitamin B6 deficiency: A potential cause of refractory Seizures in adults. Journal of Parenteral and Enteral Nutrition, 35(2), 272–275.
Hesdorffer, D. C., Logroscino, G., Benn, E. K. T., Katri, N., Cascino, G., & Hauser, W.
A. (2011). Estimating risk for developing epilepsy: A population-based study in Rochester, Minnesota. Neurology, 76(1), 23–27. http://www.ncbi.nlm.nih.gov/pubmed/3032191%5Cnhttp://www.neurology.org/cg i/doi/10.1212/WNL.0b013e318204a36a

PDF

Published
November 20 , 2022

Issue
Vol. 1 No. 1 (2022)

Section
Research Article

Under License of Creative Commons Attribution ShareAlike 4.0 International Generic (CC BY-SA 4.0).

Page updated

Report abuse